Carbon Dioxide → HCID 17984209, compound

Participants

Reaction Steps

The crude malonic acid 13 (250 mg, 0.957 mmol) was placed in a round bottom flask under vacuum and slowly heated to between 150 and 200° C., as the evolution of CO2 occurred. As the bubbling ended, the reaction was heated for 2 more additional minutes, then allowed to cool to room temperature. The product was purified by flash chromatography three times using 0 to 10% MeOH in CHCl3 to give compound 14 as a solid (120 mg; 57.7% yield; M−1=216.3).

Provenance & Evidence