Hydrochloric Acid → HCID 135899325, compound

Participants

Reaction Steps

Hydrogen peroxide (3% in H2O, 2.8 ml) and ethanol (0.6 ml) were added to a suspension of N-(3-cyano-pyridin-2-yl)-2-[2-(4-fluoro-phenyl)-ethoxy]-acetamide (900 mg, 3 mmol) in 5N NaOH (11 ml), and the mixture was heated to reflux (4 h). Upon cooling, the solution was diluted with water and acidified (HCl, pH ˜3). The precipitated title compound was filtered off, triturated with tert-butyl methyl ether, and dried. MS: m/e=300.3 [M+H+], 1H NMR (d6-DMSO): 2.89 (t, 2H), 3.77 (t, 2H), 4.45 (s, 2H), 7.04-7.12 (m, 2H), 7.28-7.33 (m, 2H), 7.54 (dd, 1H), 8.50 (d, 1H), 8.95 (d, 1H), 12.45 (bs, 1H).

Provenance & Evidence