Potassium tert-butoxide → HCID 135899182, compound

HRID 2100486Notes

Reaction equation

HRID 2100486 reaction equation
Cl[C:2]1[N:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:3]=1[C:4]([NH:6][C:7](=[NH:19])[CH2:8][O:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)=[O:5].CC([O-])(C)C.[K+]>>[Cl:24][C:21]1[CH:22]=[N:23][C:2]2[N:19]=[C:7]([CH2:8][O:9][CH2:10][CH2:11][C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[NH:6][C:4](=[O:5])[C:3]=2[CH:20]=1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 140520073HCID 140520073, compound

Product 1

HCID 135899182HCID 135899182, compound

Procedure

In analogy to the procedure described in example 78.4, 2,5-dichloro-N-{2-[2-(4-fluoro-phenyl)-ethoxy]-1-imino-ethyl}-nicotinamide was treated with KOtBu to obtain 6-chloro-2-[2-(4-fluoro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one as yellow crystals. MS: m/e=334.4 [M+H+].

Sources & evidence

ORD record
ord-99f87783979d4854a42ad0ec5b41fd44
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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