HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 2,5-dichloro-N-[2-[2-(3-chloro-4-fluorophenyl)ethoxy]ethanimidoyl]pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2,5-Dichloropyridine-3-carboxylic acid | HCID 2736085 | — |
| Reactant | 2-[2-(3-Chloro-4-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride | HCID 67098397 | — |
| Product | 2,5-dichloro-N-[2-[2-(3-chloro-4-fluorophenyl)ethoxy]ethanimidoyl]pyridine-3-carboxamide | HCID 140520070 | — |
Reaction Steps
In analogy to the procedure described in example 78.3, 2,5-dichloronicotinic acid was reacted with 2-[2-(3-chloro-4-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride in the presence of TBTU and DIPEA to give 2,5-dichloro-N-{2-[2-(3-chloro-4-fluoro-phenyl)-ethoxy]-1-imino-ethyl}-nicotinamide as orange oil. MS: m/e=404.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-ed5596dbcdf547a0b09b422da044bfc2 |
| Source note | uspto-grants-2009_08 |