HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 6-chloro-2-[2-(3-chloro-4-fluoro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 2,5-dichloro-N-[2-[2-(3-chloro-4-fluorophenyl)ethoxy]ethanimidoyl]pyridine-3-carboxamide | HCID 140520070 | — |
| Product | 6-chloro-2-[2-(3-chloro-4-fluoro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one | HCID 135899183 | — |
Reaction Steps
In analogy to the procedure described in example 78.4, 2,5-dichloro-N-{2-[2-(3-chloro-4-fluoro-phenyl)-ethoxy]-1-imino-ethyl}-nicotinamide was treated with KOtBu to obtain 6-chloro-2-[2-(3-chloro-4-fluoro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one as orange crystals. MS: m/e=368.0 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-e21fd43a7ac94565bcb4c65f5597d97d |
| Source note | uspto-grants-2009_08 |