Diisopropylethylamine → HCID 136345880, compound

Participants

Reaction Steps

A solution of 2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-nicotinamide (7.24 g, 22.3 mmol) and DIPEA (14.4 ml, 111.6 mmol) in DMF (250 ml) was stirred overnight at 100° C. The reaction mixture was evaporated, redissolved in toluene and brought to dryness under reduced pressure. The residue was triturated with 100 ml EtOAc/MeOH (19/1) and filtrated to yield 2-(4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylmethyl)-isoindole-1,3-dione (6.03 g, 19.7 mmol; 88%) as light brown solid. MS (m/e): 307.2 [M+H+].

Provenance & Evidence