2,6-Difluoropyridine-3-carboxylic acid → 2-[2-(3-Chloro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one

HRID 2100499Notes

Reaction equation

HRID 2100499 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[C:4]([F:11])[N:3]=1.Cl.[Cl:13][C:14]1[CH:15]=[C:16]([CH2:20][CH2:21][O:22][CH2:23][C:24]([NH2:26])=[NH:25])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[CH:15]=[C:16]([CH2:20][CH2:21][O:22][CH2:23][C:24]2[NH:26][C:8](=[O:10])[C:7]3[CH:6]=[CH:5][C:4]([F:11])=[N:3][C:2]=3[N:25]=2)[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 105830702,6-Difluoropyridine-3-carboxylic acidHCID 67098848HCID 67098848, compound

Product 1

HCID 1358991932-[2-(3-Chloro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one

Procedure

The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(3-chloro-phenyl)-ethoxy]-acetamidine hydrochloride (example 79.2). Light brown solid. MS: m/e=334.1 [M+H+].

Sources & evidence

ORD record
ord-cdef599c18f043b3bbf5de860d2e2b34
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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