2-Aminopyridine-3-carboxamide → HCID 135899199, compound

Participants

Reaction Steps

In analogy to example 91.3, 2-amino-nicotinamide and [2-(3-methoxy-phenyl)-ethoxy]-acetic acid methyl ester (prepared from 2-(3-methoxyphenyl)ethanol [5020-41-7] in analogy to example 91.1-91.2) reacted in the presence of LiHMDS in THF to yield after purification of the crude product with column chromatography (silica gel, EtOAc) 2-[2-(3-methoxy-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one as white solid. MS (m/e): 312.2 [M+H+].

Provenance & Evidence