反应详情

Thionylchloride (288 μl, 3.98 mmol) was added dropwise to a solution of 5-(4-fluoro-phenyl)-pentanoic acid (520 mg, 2.65 mmol) in methanol (11 ml) at −15° C. The reaction mixture was then stirred at room temperature for 1.5 h. Water was added and the mixture was extracted 3 times with diethylether. The combined extracts were washed with water and brine, dried (Na2SO4) and evaporated. The remaining residue was purified by column chromatography (silica gel, ethyl acetate/heptane 5:95 to 12:88) to obtain 5-(4-fluoro-phenyl)-pentanoic acid methyl ester (420 mg, 2 mmol; 75%) as colorless liquid. MS: m/e 211.0 [M+H+].

1. extractionthe mixture was extracted 3 times with diethylether
2. washThe combined extracts were washed with water and brine
3. dry with materialdried (Na2SO4)
4. customevaporated
5. customThe remaining residue was purified by column chromatography (silica gel, ethyl acetate/heptane 5:95 to 12:88)