HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl iodoacetate → [2-(3-Trifluoromethyl-phenyl)-ethoxy]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl iodoacetate | HCID 12183 | — |
| Reactant | 2,6-Di-tert-butylpyridine | HCID 68510 | — |
| Reactant | 3-(Trifluoromethyl)phenethylic alcohol | HCID 95926 | — |
| Catalyst | Silver(I) trifluoromethanesulfonate | HCID 76223 | — |
| Product | [2-(3-Trifluoromethyl-phenyl)-ethoxy]-acetic acid ethyl ester | HCID 68565644 | — |
Reaction Steps
In analogy to the procedure described in example 78.1, 2-(3-trifluoromethyl-phenyl)-ethanol was reacted with ethyl iodoacetate in the presence of silver trifluoromethanesulfonate and 2,6-di-tert-butylpyridin to give [2-(3-trifluoromethyl-phenyl)-ethoxy]-acetic acid ethyl ester as colorless liquid. MS: m/e=277.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-d72ff45677254dbba9d0958366b8fe72 |
| Source note | uspto-grants-2009_08 |