2,6-Difluoropyridine-3-carboxylic acid → HCID 135899208, compound

HRID 2100514Notes

Reaction equation

HRID 2100514 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[C:4]([F:11])[N:3]=1.Cl.[F:13][C:14]([F:29])([F:28])[C:15]1[CH:16]=[C:17]([CH2:21][CH2:22][O:23][CH2:24][C:25]([NH2:27])=[NH:26])[CH:18]=[CH:19][CH:20]=1>>[F:11][C:4]1[CH:5]=[CH:6][C:7]2[C:8](=[O:10])[NH:27][C:25]([CH2:24][O:23][CH2:22][CH2:21][C:17]3[CH:18]=[CH:19][CH:20]=[C:15]([C:14]([F:13])([F:28])[F:29])[CH:16]=3)=[N:26][C:2]=2[N:3]=1

Participants

3

Reactant 2

HCID 105830702,6-Difluoropyridine-3-carboxylic acidHCID 68564898HCID 68564898, compound

Product 1

HCID 135899208HCID 135899208, compound

Procedure

The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(3-trifluoromethyl-phenyl)-ethoxy]-acetamidine hydrochloride. Brown solid. MS: m/e=368.1 [M+H+].

Sources & evidence

ORD record
ord-d54b10327dcb472182fa327133a45aed
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

Loading…