Sodium Hydroxide → HCID 136345808, compound

HRID 2100520Notes

Reaction equation

HRID 2100520 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:11]=[CH:10][C:9]([CH3:12])=[N:8][C:6]=2[N:7]=1.[OH-:14].[Na+]>>[ClH:1].[Cl:1][C:2]1[NH:3][C:4](=[O:14])[C:5]2[CH:11]=[CH:10][C:9]([CH3:12])=[N:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 717430672,4-Dichloro-7-methylpyrido[2,3-d]pyrimidine

Product 1

HCID 136345808HCID 136345808, compound

Procedure

In analogy to the procedure described in example 97.2, 2,4-dichloro-7-methyl-pyrido[2,3-d]pyrimidine (R. K. Robins, G. H. Hitchings, J. Am. Chem. Soc. 1958, 80, 3449-57) was treated with 1N NaOH solution to give 2-chloro-7-methyl-3H-pyrido[2,3-d]pyrimidin-4-one hydrochloride as orange solid. MS: m/e=196.1 [M+H+].

Sources & evidence

ORD record
ord-1dfa1e4c79394e3484828edaa092d2fe
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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