2,6-Difluoropyridine-3-carboxylic acid → 7-Fluoro-2-[2-(3-fluoro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one

HRID 2100524Notes

Reaction equation

HRID 2100524 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[C:4]([F:11])[N:3]=1.Cl.[F:13][C:14]1[CH:15]=[C:16]([CH2:20][CH2:21][O:22][CH2:23][C:24]([NH2:26])=[NH:25])[CH:17]=[CH:18][CH:19]=1>>[F:11][C:4]1[CH:5]=[CH:6][C:7]2[C:8](=[O:10])[NH:26][C:24]([CH2:23][O:22][CH2:21][CH2:20][C:16]3[CH:17]=[CH:18][CH:19]=[C:14]([F:13])[CH:15]=3)=[N:25][C:2]=2[N:3]=1

Participants

3

Reactant 2

HCID 105830702,6-Difluoropyridine-3-carboxylic acidHCID 685680012-[2-(3-Fluoro-phenyl)-ethoxy]-acetamidine hydrochloride

Product 1

HCID 1358992117-Fluoro-2-[2-(3-fluoro-phenyl)-ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one

Procedure

The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(3-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride. Light brown solid. MS: m/e=318.1 [M+H+].

Sources & evidence

ORD record
ord-33b4b48ad2d94bcfa7af202879ef18b1
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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