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Ethyl iodoacetate → [2-(2-Chloro-phenyl)-ethoxy]-acetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl iodoacetate | HCID 12183 | — |
| 反応物 | 2,6-Di-tert-butylpyridine | HCID 68510 | — |
| 反応物 | o-Chlorophenethylic alcohol | HCID 88266 | — |
| 触媒 | Silver(I) trifluoromethanesulfonate | HCID 76223 | — |
| 生成物 | [2-(2-Chloro-phenyl)-ethoxy]-acetic acid ethyl ester | HCID 68567706 | — |
反応手順
In analogy to the procedure described in example 78.1, 2-(2-chloro-phenyl)-ethanol was reacted with ethyl iodoacetate in the presence of silver trifluoromethanesulfonate and 2,6-di-tert-butylpyridin to give [2-(2-chloro-phenyl)-ethoxy]-acetic acid ethyl ester as yellow liquid. 1H NMR (CDCl3): 1.28 (t, J=7.3 Hz, 3H), 3.09 (t, J=7.1 Hz, 2H), 3.78 (t, J=7.1 Hz, 2H), 4.09 (s, 2H), 4.21 (q, J=7.3 Hz, 2H), 7.13-7.23 (m, 2H), 7.29-7.37 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07572801B2 |
| 出典データセット | uspto-grants-2009_08 |
| ORD ID | ord-d64ad3ea76274c5ebf6c4225a9a313b7 |
| 出典メモ | uspto-grants-2009_08 |