Ethyl iodoacetate → [2-(2-Chloro-6-fluoro-phenyl)-ethoxy]-acetic acid ethyl ester

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Reaction Steps

In analogy to the procedure described in example 78.1, 2-(2-chloro-6-fluoro-phenyl)-ethanol was reacted with ethyl iodoacetate in the presence of silver trifluoromethanesulfonate and 2,6-di-tert-butylpyridin to give [2-(2-chloro-6-fluoro-phenyl)-ethoxy]-acetic acid ethyl ester as colorless liquid. 1H NMR (CDCl3): 1.28 (t, J=7.1 Hz, 3H), 3.15 (t, J=7.1 Hz, 2H), 3.73 (t, J=7.3 Hz, 2H), 4.11 (s, 2H), 4.22 (q, J=7.1 Hz, 2H), 6.96 (m, 1H), 7.09-7.19 (m, 2H).

Provenance & Evidence