2,6-Difluoropyridine-3-carboxylic acid → HCID 136368390, compound

HRID 2100534Notes

Reaction equation

HRID 2100534 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[C:4]([F:11])[N:3]=1.Cl.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1[CH2:21][CH2:22][O:23][CH2:24][C:25]([NH2:27])=[NH:26]>>[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1[CH2:21][CH2:22][O:23][CH2:24][C:25]1[NH:27][C:8](=[O:10])[C:7]2[CH:6]=[CH:5][C:4]([F:11])=[N:3][C:2]=2[N:26]=1

Participants

3

Reactant 2

HCID 105830702,6-Difluoropyridine-3-carboxylic acidHCID 68570404HCID 68570404, compound

Product 1

HCID 136368390HCID 136368390, compound

Procedure

The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(2-chloro-6-fluoro-phenyl)-ethoxy]-acetamidine hydrochloride. Off-white solid. MS: m/e=352.2 [M+H+].

Sources & evidence

ORD record
ord-40b3caffe27946aba8f4e8360b5d24ae
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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