HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoropyridine-3-carboxylic acid → 2-[2-(2,5-Difluoro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoropyridine-3-carboxylic acid | HCID 10583070 | — |
| Reactant | 2-[2-(2,5-Difluoro-phenyl)-ethoxy]-acetamidine hydrochloride | HCID 67099036 | — |
| Product | 2-[2-(2,5-Difluoro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one | HCID 136368393 | — |
Reaction Steps
The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(2,5-difluoro-phenyl)-ethoxy]-acetamidine hydrochloride (example 78.2). Off-white solid. MS: m/e=336.3 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-c08d0f96289e4ba79c53e4d15a81b114 |
| Source note | uspto-grants-2009_08 |