2,6-Difluoropyridine-3-carboxylic acid → HCID 136368394, compound

HRID 2100539Notes

Reaction equation

HRID 2100539 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[C:4]([F:11])[N:3]=1.Cl.[F:13][C:14]([F:30])([F:29])[O:15][C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][O:24][CH2:25][C:26]([NH2:28])=[NH:27])[CH:19]=[CH:20][CH:21]=1>>[F:11][C:4]1[CH:5]=[CH:6][C:7]2[C:8](=[O:10])[NH:28][C:26]([CH2:25][O:24][CH2:23][CH2:22][C:18]3[CH:19]=[CH:20][CH:21]=[C:16]([O:15][C:14]([F:13])([F:29])[F:30])[CH:17]=3)=[N:27][C:2]=2[N:3]=1

Participants

3

Reactant 2

HCID 105830702,6-Difluoropyridine-3-carboxylic acidHCID 68567664HCID 68567664, compound

Product 1

HCID 136368394HCID 136368394, compound

Procedure

The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(3-trifluoromethoxy-phenyl)-ethoxy]-acetamidine hydrochloride (example 81.2). Light brown solid. MS: m/e=384.1 [M+H+].

Sources & evidence

ORD record
ord-b9f0d286c5a34c4fa792445fc1abe558
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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