2,5-difluoropyridine-3-carboxylic Acid → 2-[2-(2,5-Difluoro-phenyl)-ethoxymethyl]-6-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one

HRID 2100541Notes

Reaction equation

HRID 2100541 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][C:5]([F:11])=[CH:4][N:3]=1.Cl.[F:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[CH2:21][CH2:22][O:23][CH2:24][C:25]([NH2:27])=[NH:26]>>[F:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[CH2:21][CH2:22][O:23][CH2:24][C:25]1[NH:27][C:8](=[O:10])[C:7]2[CH:6]=[C:5]([F:11])[CH:4]=[N:3][C:2]=2[N:26]=1

Participants

3

Reactant 2

HCID 118159992,5-difluoropyridine-3-carboxylic AcidHCID 670990362-[2-(2,5-Difluoro-phenyl)-ethoxy]-acetamidine hydrochloride

Product 1

HCID 1363683962-[2-(2,5-Difluoro-phenyl)-ethoxymethyl]-6-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one

Procedure

The title compound was prepared in analogy to example 85 from 2,5-difluoropyridine-3-carboxylic acid and 2-[2-(2,5-difluoro-phenyl)-ethoxy]-acetamidine hydrochloride (example 78.2). Light brown solid. MS: m/e=336.3 [M+H+].

Sources & evidence

ORD record
ord-6d599f7812024560adb7c68cf899bcf2
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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