HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 2-chloro-N-[2-[2-(3-chlorophenyl)ethoxy]ethanimidoyl]-5-ethylpyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2-Chloro-5-ethyl-nicotinic acid | HCID 20078680 | — |
| Reactant | HCID 67098848 | HCID 67098848 | — |
| Product | 2-chloro-N-[2-[2-(3-chlorophenyl)ethoxy]ethanimidoyl]-5-ethylpyridine-3-carboxamide | HCID 140520067 | — |
Reaction Steps
In analogy to the procedure described in example 78.3, 2-chloro-5-ethyl-nicotinic acid (example 124.1) was reacted with 2-[2-(3-chloro-phenyl)-ethoxy]-acetamidine hydrochloride (example 79.2) in the presence of TBTU and DIPEA to give 2-chloro-N-{2-[2-(3-chloro-phenyl)-ethoxy]-1-imino-ethyl}-5-ethyl-nicotinamide as yellow oil. MS: m/e=380.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-10e87c1c17ef4e04b5222571e11a2c5d |
| Source note | uspto-grants-2009_08 |