HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 5-butyl-2-chloro-N-[2-[2-(2,5-difluorophenyl)ethoxy]ethanimidoyl]pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2-[2-(2,5-Difluoro-phenyl)-ethoxy]-acetamidine hydrochloride | HCID 67099036 | — |
| Reactant | 5-Butyl-2-chloro-nicotinic acid | HCID 86616609 | — |
| Product | 5-butyl-2-chloro-N-[2-[2-(2,5-difluorophenyl)ethoxy]ethanimidoyl]pyridine-3-carboxamide | HCID 140520066 | — |
Reaction Steps
In analogy to the procedure described in example 78.3, 5-butyl-2-chloro-nicotinic acid (example 126.3) was reacted with 2-[2-(2,5-difluoro-phenyl)-ethoxy]-acetamidine hydrochloride (example 78.2) in the presence of TBTU and DIPEA to give 5-butyl-2-chloro-N-{2-[2-(2,5-difluoro-phenyl)-ethoxy]-1-imino-ethyl}-nicotinamide as orange oil. MS: m/e=410.1 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572801B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-e37acd02a3db4a3892e1fb356be06cdc |
| Source note | uspto-grants-2009_08 |