Hydrochloric Acid → HCID 69057447, compound

Participants

Reaction Steps

To a solution of 3-(10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-4-(2-isopropoxycarbonyl-3-trifluoromethyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (625 mg, 0.97 mmol)) in 20 mL of 2:1 THF/H2O was added lithium hydroxide (70 mg, 2.91 mmol). The reaction mixture was allowed to stir at ambient temperature for 18 h. The reaction was acidified with 1 N HCl and extracted with EtOAc. The EtOAc layer was washed with brine, dried (MgSO4) and concentrated to afford 0.60 g of a mixture of the title compound and (1R)-(+)-2,10-camphorsultam, which was used without purification. LRMS (ES)+: 446.28 (M+H)+.

Provenance & Evidence