Hydrochloric Acid → HCID 131727572, compound

Participants

Reaction Steps

To a solution of (±)-trans-1-tert-butyl 3-methyl 4-(3-chloro-2-(ethoxycarbonyl)-5-propylphenyl)pyrrolidine-1,3-dicarboxylate (0.78 g, 1.72 mmol) in 20 mL of THF and 10 mL of water was added lithium hydroxide (0.051 g, 2.15 mmol). The reaction was stirred at ambient temperature for 3 h and then was acidified with 1N HCl. The reaction mixture was extracted with EtOAc and the organics were washed with brine, dried (MgSO4) and concentrated to afford 0.75 g (98%) of the title compound as a white foam. LRMS (ES)+: 340.17/342.16 (M+H—BOC)+.

Provenance & Evidence