HCID 69055020, compound → HCID 69055626, compound

Participants

Reaction Steps

Following the procedure described in Example 23, Part K, (3aR,9bS)-tert-butyl 6-chloro-5-oxo-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]isoquinoline-2(9bH)-carboxylate, the first eluting compound from Part B above, was converted into the title compound of Example 27 as an off-white solid. 1H NMR (DMSO-D6): δ 10.03 (broad s, 1H), 9.80 (broad s, 1H), 8.87 (s, 1H), 7.55-7.45 (m, 2H), 7.22 (d, 1H), 3.92-3.84 (m, 1H), 3.63-3.53 (m, 1H), 3.50-3.42 (m, 1H), 3.32-3.22 (m, 1H), 3.20-3.05 (overlapping m, 2H). LRMS (ESI): 223.07/225.05 (M+H)+.

Provenance & Evidence