2-chloro-N,N-diethyl-4-methylbenzamide → HCID 11659097, compound

Participants

Reaction Steps

Following the procedure described in Example 23, Part K, (3aS,9bR)-tert-butyl 6-chloro-5-oxo-8-methyl-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]isoquinoline-2(9bH)-carboxylate, the second eluting compound from Example 37, Part C, was converted into the title compound of Example 38 as an off-white solid. 1H NMR (DMSO-D6): δ 9.55 (broad s, 1H), 9.41 (broad s, 1H), 8.67 (s, 1H), 7.29 (s, 1H), 7.02 (s, 1H), 3.85-3.80 (m, 1H), 3.66-3.61 (m, 1H), 3.58-3.52 (m, 1H), 3.30-3.25 (m, 1H), 3.15-3.10 (m, 1H), 3.07-3.02 (m, 1H), 2.30 (s, 3H). LRMS (ESI): 237.1/239.1 (M+H)+.

Provenance & Evidence