HCID 69052100, compound → HCID 11601504, compound

Participants

Reaction Steps

Following the procedure described in Example 45, Part I, (3aR,9bS)-tert-butyl 6-chloro-9-methyl-5-oxo-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]isoquinoline-2(9bH)-carboxylate, the second eluting compound from Part B above, was converted into the title compound of Example 54 as a white solid. 1H NMR (DMSO-D6): δ 9.77 (broad s, 1H), 9.63 (broad s, 1H), 8.89 (s, 1H), 7.37 (d, 1H, J=8.2 Hz), 7.32 (d, 1H, J=8.2 Hz), 4.02-3.96 (m, 1H), 3.65-3.60 (m, 1H), 3.47-3.41 (m, 1H), 3.35-3.27 (m, 2H), 3.10-3.02 (m, 1H), 2.26 (s, 3H). LRMS (ESI): 237.2/239.2 (M+H)+.

Provenance & Evidence