HCID 69055164, compound → HCID 11630622, compound

Participants

Reaction Steps

Following the procedure described in Example 45, Part I, (3aR,9bS)-tert-butyl 6-chloro-9-ethyl-5-oxo-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]isoquinoline-2(9bH)-carboxylate, the first eluting compound from Part B above, was converted into the title compound of Example 56 as a white solid. 1H NMR (DMSO-D6): δ 9.77 (broad s, 1H), 9.61 (broad s, 1H), 8.84 (s, 1H), 7.32 (d, 1H, J=8.2 Hz), 7.27 (d, 1H, J=8.2 Hz), 3.93-3.86 (m, 1H), 3.60-3.53 (m, 1H), 3.33-3.20 (m, 3H), 3.04-2.96 (m, 1H), 2.47 (q, 2H, J=7.5 Hz), 1.05 (t, 3H, J=7.5 Hz). LRMS (ESI): 251.1/253.1 (M+H)+.

Provenance & Evidence