HCID 69055164, compound → HCID 11500414, compound

Participants

Reaction Steps

Following the procedures described in Example 15, Part A and Example 45, Part I, (3aR,9bS)-tert-butyl 6-chloro-9-ethyl-5-oxo-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]isoquinoline-2(9bH)-carboxylate, the first eluting compound from Example 56, Part B, was converted into the title compound of Example 58 as an pale yellow solid. 1H NMR (DMSO-D6): δ 9.84 (broad s, 1H), 9.79 (broad s, 1H), 7.33 (d, 1H, J=8.2 Hz), 7.26 (d, 1H, J=8.2 Hz), 3.98-3.92 (m, 1H), 3.78-3.71 (m, 1H), 3.62-3.48 (m, 2H), 3.35-3.20 (m, 2H), 2.93 (s, 3H), 2.47 (q, 2H, J=7.4 Hz), 1.05 (t, 3H, J=7.5 Hz). LRMS (ESI): 265.1/267.1 (M+H)+.

Provenance & Evidence