HCID 69054892, compound → HCID 69059486, compound

HRID 2100621Notes

Reaction equation

HRID 2100621 reaction equation
[Cl:1]C1C2C(=O)N[C@H]3CN(C(OC(C)(C)C)=O)C[C@@H]3C=2C=CC=1C.[Cl:24][C:25]1[C:34]2[C:33](=[O:35])[NH:32][C@@H:31]3[CH2:36][N:37](C(OC(C)(C)C)=O)[CH2:38][C@H:30]3[C:29]=2[CH:28]=[CH:27][C:26]=1[CH3:46]>>[ClH:1].[Cl:24][C:25]1[C:34]2[C:33](=[O:35])[NH:32][C@H:31]3[CH2:36][NH:37][CH2:38][C@@H:30]3[C:29]=2[CH:28]=[CH:27][C:26]=1[CH3:46]

Participants

3

Reactant 2

HCID 69054892HCID 69054892, compoundHCID 69056475HCID 69056475, compound

Product 1

HCID 69059486HCID 69059486, compound

Procedure

Following the procedure described in Example 45, Part I, (3aR,9bS)-tert-butyl 6-chloro-7-methyl-5-oxo-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]isoquinoline-2(9bH)-carboxylate, the first eluting compound from Part B above, was converted into the title compound of Example 68 as a white solid. LRMS (ESI): 237.0/239.0 (M+H)+.

Sources & evidence

ORD record
ord-55c876bf96e24f4597abadc3d9ee2260
Source dataset
uspto-grants-2009_08
Patent number
US07572805B2

Reaction notes

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