Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphine | HCID 24404 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 1-BROMO-2-ETHYL-4-METHOXY-BENZENE | HCID 12386619 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 68815759 | HCID 68815759 | — |
Reaction Steps
1-Bromo-2-ethyl-4-methoxy-benzene (1 eq), piperazine-1-carboxylic acid tert-butyl ester (1.5 eq), Pd(OAc)2 (0.03 eq), phosphine ligand (0.06 eq), sodium t-butoxide (1.7 eq) are mixed in toluene and the resulting mixture is heated at 120° C. in microwave for 20 minutes. It is then diluted with EtOAc/hexane and filtered through celite. Flash column chromatography (20% EtOAc/hexane) gave 4-(2-Ethyl-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester. MS: (ES+): 321.2 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07572811B2 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-d2b2efc0f48b465abab3bd08d0b67024 |
|---|
| Source note | uspto-grants-2009_08 |
|---|
