HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 68812043, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | HCID 68815759 | HCID 68815759 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | HCID 68812043 | HCID 68812043 | — |
Reaction Steps
4-(2-Ethyl-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester is refluxed in 48% HBr for 2 hours. After concentration, the residue is dissolved in DCM and (Boc)2O (1.5 eq) and triethylamine (4 eq) are added. The resulting mixture is stirred at room temperature for 30 minutes. After aqueous workup, flash column chromatography (30% EtOAc/hexane) gave 4-(2-Ethyl-4-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester. MS: (ES+): 307.2 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572811B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-fe3935359edf48d8b726f529c0313c4f |
| Source note | uspto-grants-2009_08 |