反应详情

温度

130 °C

2-Cyanomethyl-benzoic acid (1.61 g, 0.01 mol), 3-amino-5-methylpyrazol (1 g, 0.01 mol) and acetic acid (15 ml) were sealed in a bottle. The mixture was heated at 130° C. for 20 minutes under microwave irradiation. The mixture was concentrated, and the residue was dissolved in 5 ml methanol (MeOH). The resulting solution was added dropwise to 200 ml water. After stirred for 1 hour, the solid was collected, and dried to give product (1.8 g, 75% yield). LC-MS: 241 (MH+)

1. concentrationThe mixture was concentrated
2. dissolutionthe residue was dissolved in 5 ml methanol (MeOH)
3. additionThe resulting solution was added dropwise to 200 ml water
4. customthe solid was collected
5. customdried