反应详情

温度

130 °C

2-Cyanomethyl-benzoic acid (1.61 g, 0.01 mol), 3-amino-pyrazole (1 g, 0.01 mol), acetic acid (15 ml), were sealed in a bottle (20 ml). The mixture was heated at 130° C. for 20 minutes under microwave irradiation. The mixture was concentrated and the residue was dissolved in 5 ml MeOH. The solution was added dropwise to 200 ml water. After stirred for 1 hour, solid was collected and dried to give product (1.8 g, 75% yield). LC-MS: 227 (MH+)

1. concentrationThe mixture was concentrated
2. dissolutionthe residue was dissolved in 5 ml MeOH
3. additionThe solution was added dropwise to 200 ml water
4. customsolid was collected
5. customdried