Hydrochloric Acid → 3-(4-Fluoro-3-methoxyphenyl)prop-2-enoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-Fluoro-3-methoxy-benzaldehyde (6.16 g, 40 mmol), and malonic acid (6.24 g, 60 mmol) in pyridine (30 ml) and piperidine (1 ml) was heated at 120° C. for 2 hrs. The mixture was cooled to room temperature and neutralized with concentrated HCl to PH<3, the white solid was collected and dried to give 7.6 g of product (97% yield). LC-MS: m/e 195 (M−1)

Provenance & Evidence