HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Fluoro-5-methoxy-indan-1,2-dione 2-oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Butyl nitrite | HCID 10996 | — |
| Reactant | 6-Fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one | HCID 55297158 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Fluoro-5-methoxy-indan-1,2-dione 2-oxime | HCID 76608778 | 70% |
Reaction Steps
To a solution of 6-Fluoro-5-methoxy-indan-1-one (4.8 g) in 65 ml of MeOH was added 2.7 ml of concentrated HCl, then a solution of n-butylnitrite (3.47 ml) at room temperature. The resulting mixture was stirred for 2 hrs, the precipitate was collected and dried to yield the product as a white solid (3.9 g, 70% yield). LC-MS: m/e 210 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572809B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-bf9c5b68338a4a45a22a26ae19da139e |
| Source note | uspto-grants-2009_08 |