反应详情

温度

130 °C

2-Cyanomethyl-5-fluoro-4-methoxy-benzoic acid (1.75 g), 3-amino-5-methylpyrazol (1.63 g), acetic acid (15 ml), were sealed in a process vial. The mixture was heated at 130° C. for 30 minutes under microwave irradiation. The mixture was concentrated, and the residue was dissolved in 5 ml MeOH. The resulting solution was added dropwise to 200 ml water. After stirred for 1 hour, the solid was collected, and dried to give product (1.85 g, 77% yield). LC-MS: m/e 289 (MH+)

1. concentrationThe mixture was concentrated
2. dissolutionthe residue was dissolved in 5 ml MeOH
3. additionThe resulting solution was added dropwise to 200 ml water
4. customthe solid was collected
5. customdried