Phosphorus oxychloride → HCID 57799568, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-Methoxy-7-(2-methoxy-ethoxy)-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ol (1.0 g, 1.45 mmol) in POCl3 (20 ml) was sealed in 2 microwave process vial (20 ml). The mixture was heated at 160° C. for 30 minutes under microwave irradiation. After removal of excess solvent, the residue was poured into ice-water, neutralized by 2M NaOH, extracted by EtOAc. The organic layer was concentrated and the residue was purified by flash column chromatography to give product as solid (0.33 g, 62.7%). LC-MS: m/e 363 (MH+).

Provenance & Evidence