Azane;hydrate → HCID 57799811, compound

HRID 2100756Notes

Reaction equation

HRID 2100756 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][CH2:9][C:8]2=[O:16])=O.[NH3:17].O>>[CH3:15][O:14][C:13]1[CH:12]=[C:11]2[C:7]([C:8](=[O:16])[CH2:9][CH2:10]2)=[CH:6][C:5]=1[C:3]([NH2:17])=[O:2]

Participants

3

Reactant 2

HCID 12896473Azane;hydrateHCID 57799525HCID 57799525, compound

Product 1

HCID 57799811HCID 57799811, compoundYield 80%

Conditions

Temperature
40 °C

Procedure

6-Methoxy-3-oxo-indan-5-carboxylic acid methyl ester (7 g, 31.82 mmol) was suspended in NH3.H2O (150 ml), and the mixture was heated to 40° C. and stirred for two hours, during this time the precipitate was formed. The precipitate was collected and dried to give product as white solid (5.2 g, 80% yield). LC-MS: m/e 206(MH+)

Workup

  1. customwas formed
  2. customThe precipitate was collected
  3. customdried

Sources & evidence

ORD record
ord-c725e948ef78416f83cc9020152519e1
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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