Phenol → HCID 57799472, compound

HRID 2100762Notes

Reaction equation

HRID 2100762 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[C:11]([NH:19][C:20]2[CH:24]=[C:23]([CH3:25])[NH:22][N:21]=2)[N:10]=1>>[CH3:25][C:23]1[NH:22][N:21]=[C:20]([NH:19][C:11]2[N:10]=[C:9]([O:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[C:18]3[C:13]([CH:12]=2)=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:24]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 57799635(1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 57799472HCID 57799472, compound

Procedure

Similar procedure as described in example 10 was used, starting from phenol and (1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give (5-methyl-1H-pyrazol-3-yl)-(1-phenoxy-isoquinolin-3-yl)-amine. LC-MS: m/e 317 (MH+). 1H NMR(DMSO): δ 2.12(s, 3H), δ 5.56(s, 1H), δ 7.22(s, 1H), δ 7.32(m, 5H), δ 7.51(m, 2H), δ 7.65(m, 2H), δ 8.15(d, 1H), δ 9.05(s, 1H).

Sources & evidence

ORD record
ord-39b1564a73154d768e15911dd9c2635e
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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