3-(Trifluoromethyl)phenol → HCID 57799688, compound

HRID 2100779Notes

Reaction equation

HRID 2100779 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.Cl[C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[C:15]([NH:23][C:24]2[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=2)[N:14]=1>>[CH3:29][C:27]1[NH:26][N:25]=[C:24]([NH:23][C:15]2[N:14]=[C:13]([O:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=3)[C:22]3[C:17]([CH:16]=2)=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:28]=1

Participants

3

Reactant 2

HCID 73763-(Trifluoromethyl)phenolHCID 57799635(1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 57799688HCID 57799688, compound

Procedure

Similar procedure as described in example 10 was used, starting from 3-trifluoromethyl-phenol and (1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give (5-methyl-1H-pyrazol-3-yl)-[1-(3-trifluoromethyl-phenoxy)-isoquinolin-3-yl]-amine. LC-MS m/e 385(MH+).

Sources & evidence

ORD record
ord-fb8b579b5b38452293c455c6511de8e5
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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