M-Cresol → HCID 57799796, compound

HRID 2100791Notes

Reaction equation

HRID 2100791 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Cl[C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:20][CH3:21])=[CH:17][CH:18]=2)[CH:13]=[C:12]([NH:22][C:23]2[CH:27]=[C:26]([CH3:28])[NH:25][N:24]=2)[N:11]=1>>[CH3:28][C:26]1[NH:25][N:24]=[C:23]([NH:22][C:12]2[N:11]=[C:10]([O:8][C:4]3[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][CH:5]=3)[C:19]3[C:14]([CH:13]=2)=[CH:15][C:16]([O:20][CH3:21])=[CH:17][CH:18]=3)[CH:27]=1

Participants

3

Reactant 2

HCID 342M-CresolHCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 57799796HCID 57799796, compound

Procedure

Similar procedure as described in example 10 was used, starting from 3-methyl-phenol and (1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give (5-methyl-1H-pyrazol-3-yl)-(1-m-tolyloxy-6-methoxy-isoquinolin-3-yl)-amine. LC-MS m/e 361(MH+).

Sources & evidence

ORD record
ord-dd63d58160034c9ba755377d57ca863f
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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