2-Morpholinoethanol → HCID 57799587, compound

HRID 2100802Notes

Reaction equation

HRID 2100802 reaction equation
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=2)[CH:14]=[C:13]([NH:23][C:24]2[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=2)[N:12]=1>>[CH3:29][C:27]1[NH:26][N:25]=[C:24]([NH:23][C:13]2[N:12]=[C:11]([O:9][CH2:8][CH2:7][N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)[C:20]3[C:15]([CH:14]=2)=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=3)[CH:28]=1

Participants

3

Reactant 2

HCID 611632-MorpholinoethanolHCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 57799587HCID 57799587, compound

Procedure

Similar procedure as described in example 10 was used, starting from 2-morpholin-4-yl-ethanol and (1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give (5-methyl-1H-pyrazol-3-yl)-[1-(2-morpholin-4-yl-ethoxy)-6-methoxy-isoquinolin-3-yl]-amine. LC-MS m/e 384(MH+).

Sources & evidence

ORD record
ord-3a5c7062c842480f90f897414ff068b3
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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