Phenol → HCID 57799550, compound

HRID 2100835Notes

Reaction equation

HRID 2100835 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[CH:12]=[C:11]([NH:23][C:24]2[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=2)[N:10]=1>>[CH3:22][O:21][C:15]1[CH:14]=[C:13]2[C:18](=[CH:17][C:16]=1[O:19][CH3:20])[C:9]([O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[N:10][C:11]([NH:23][C:24]1[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=1)=[CH:12]2

Participants

3

Reactant 2

HCID 996PhenolHCID 57799766HCID 57799766, compound

Product 1

HCID 57799550HCID 57799550, compound

Procedure

Similar procedure as described in example 10 was used, starting from phenol and (1-chloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give (6,7-dimethoxy-1-phenoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 367(MH+).

Sources & evidence

ORD record
ord-f057fc0e53f7428a94f35b18b9de77b2
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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