Acetaminophen → HCID 178474267, compound

HRID 2100837Notes

Reaction equation

HRID 2100837 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1.Cl[C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[C:15]([NH:23][C:24]2[CH:28]=[CH:27][NH:26][N:25]=2)[N:14]=1>>[NH:26]1[CH:27]=[CH:28][C:24]([NH:23][C:15]2[N:14]=[C:13]([O:1][C:2]3[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:7]=3)[C:22]3[C:17]([CH:16]=2)=[CH:18][CH:19]=[CH:20][CH:21]=3)=[N:25]1

Participants

3

Reactant 2

HCID 1983AcetaminophenHCID 178478391HCID 178478391, compound

Product 1

HCID 178474267HCID 178474267, compound

Procedure

Similar procedure as described in example 10 was used, starting from N-(4-hydroxy-phenyl)-acetamide and (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine to give N-{4-[3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide. LC-MS m/e 360(MH+).

Sources & evidence

ORD record
ord-6a3c83eead224be49c6924ae36b3f784
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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