Acetaminophen → HCID 57799504, compound

HRID 2100838Notes

Reaction equation

HRID 2100838 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1.Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[CH:16]=[C:15]([NH:27][C:28]2[CH:32]=[C:31]([CH3:33])[NH:30][N:29]=2)[N:14]=1>>[CH3:26][O:25][C:19]1[CH:18]=[C:17]2[C:22](=[CH:21][C:20]=1[O:23][CH3:24])[C:13]([O:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:7]=1)=[N:14][C:15]([NH:27][C:28]1[CH:32]=[C:31]([CH3:33])[NH:30][N:29]=1)=[CH:16]2

Participants

3

Reactant 2

HCID 1983AcetaminophenHCID 57799766HCID 57799766, compound

Product 1

HCID 57799504HCID 57799504, compound

Procedure

Similar procedure as described in example 10 was used, starting from N-(4-hydroxy-phenyl)-acetamide and (1-chloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine to give N-{4-[6,7-dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide. LC-MS m/e 434(MH+).

Sources & evidence

ORD record
ord-b6fa98bde6474469a1bc360e34df8af4
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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