3-Fluorophenol → HCID 178505797, compound

HRID 2100854Notes

Reaction equation

HRID 2100854 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[F:18][C:19]1[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=1>>[F:18][C:19]1[CH:20]=[C:21]([CH:22]=[CH:23][CH:24]=1)[O:25][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1

Participants

3

Reactant 2

HCID 97433-FluorophenolHCID 178478391HCID 178478391, compound

Product 1

HCID 178505797HCID 178505797, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3-fluoro-phenol to give [1-(3-fluoro-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine. LC-MS m/e 321 (MH+).

Sources & evidence

ORD record
ord-1131e1016aa643d6b582982b94f03b40
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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