3-Cyanophenol → HCID 178509862, compound

HRID 2100855Notes

Reaction equation

HRID 2100855 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[C:18]([C:20]1[CH:21]=[C:22]([OH:26])[CH:23]=[CH:24][CH:25]=1)#[N:19]>>[NH:15]1[CH:16]=[CH:17][C:13]([NH:12][C:4]2[N:3]=[C:2]([O:26][C:22]3[CH:21]=[C:20]([CH:25]=[CH:24][CH:23]=3)[C:18]#[N:19])[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)=[N:14]1

Participants

3

Reactant 2

HCID 133943-CyanophenolHCID 178478391HCID 178478391, compound

Product 1

HCID 178509862HCID 178509862, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3-cyano-phenol to give 3-[3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile. LC-MS m/e 328(MH+).

Sources & evidence

ORD record
ord-f79843758c1a4317bf586ebd71ad8965
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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