Phenol → HCID 178420511, compound

HRID 2100862Notes

Reaction equation

HRID 2100862 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[C:18]1([OH:24])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[O:24]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 178478391HCID 178478391, compound

Product 1

HCID 178420511HCID 178420511, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and phenol to give (1-phenoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine. LC-MS m/e 303(MH+).

Sources & evidence

ORD record
ord-efd866d6436e42f79ad50e979cba35af
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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