Cyclobutanol → HCID 16202154, compound

HRID 2100873Notes

Reaction equation

HRID 2100873 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[C:4]([NH:16][C:17]2[CH:21]=[C:20]([CH3:22])[NH:19][N:18]=2)[N:3]=1.[CH:23]1([OH:27])[CH2:26][CH2:25][CH2:24]1>>[CH:23]1([O:27][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[CH:5]=[C:4]([NH:16][C:17]3[CH:21]=[C:20]([CH3:22])[NH:19][N:18]=3)[N:3]=2)[CH2:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 76218CyclobutanolHCID 57799766HCID 57799766, compound

Product 1

HCID 16202154HCID 16202154, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-chloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and cyclobutanol to give (1-cyclobutoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 355(MH+).

Sources & evidence

ORD record
ord-16e2f9e801f94309b02b26557a56f35a
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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