(1-Benzothiophen-3-yl)boronic acid → HCID 57799783, compound

HRID 2100937Notes

Reaction equation

HRID 2100937 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[S:21]1[CH:25]=[C:24](B(O)O)[C:23]2[CH:29]=[CH:30][CH:31]=[CH:32][C:22]1=2>>[S:21]1[CH:25]=[C:24]([C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:14][C:15]3[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=3)[N:3]=2)[C:23]2[CH:29]=[CH:30][CH:31]=[CH:32][C:22]1=2

Participants

3

Reactant 2

HCID 2776344(1-Benzothiophen-3-yl)boronic acidHCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 57799783HCID 57799783, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and benzo[b]thiophene-3-boronic acid to give (1-benzo[b]thiophen-3-yl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 387(MH+).

Sources & evidence

ORD record
ord-01a4a8b9ca9f43858946a829db52ecf4
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…